1,2-trans and regioselective glycosylation of multihydroxy sugars via a simple yet synergistic combination of BF3·Et2O in THF

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Green Chem., 2025, Advance Article
DOI: 10.1039/D4GC04572F, Paper
Open Access Open Access
Zhimei Wang, Longwei Gao, Yingjie Wang, Fuzhu Yang, Jinpeng Sang, Shuheng Pan, Xin Huang, Pan Zhang, Weijia Xie, Xiaoxing Wu, Biao Yu, Peng Xu, Xiaheng Zhang, Zhaolun Zhang, Wei Li
We describe a simple and concise protocol utilizing BF3·Et2O in THF for efficient 1,2-trans and regioselective glycosylation of multihydroxy acceptors, regardless of the use of α- or β-imidate donors.
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