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Green Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4GC05355A, Paper
Yu Zhu, Xueli Lv, Jun Hong, Shengxing Wu, Zhi Li, Minyan Wang, Xinpeng Jiang
Bicyclo[3.1.1]heptanes are generally considered important bioisosteres for meta-substituted arenes. Herein, we have developed an amine-promoted synthesis of C4-unsubstituted 2-oxa-3-azabicyclo[3.1.1]heptanes via formal dipolar [4π+2σ] cycloaddition of bicyclo[1.1.0]butanes (BCBs) with nitrones generated…
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