Metal-free C(sp3)–Si activation enables regiocontrolled [4 + 2] cycloaddition to benzosilacycloethers

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC03044G, Paper
Liuzhou Gao, Yan Wen, Yan Sun, Yuxin Sun, Jingyi Hu, Shenglong Wang, Zhenxing Li, Ying Han, Yidong Wang
A transition-metal-free strategy enables inverse site-selective [4 + 2] cycloaddition of benzosilacyclobutanes with activated ketones via DMSO-mediated C(sp3)–Si bond cleavage, contrasting conventional transition-metal-catalyzed pathways.
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