Replace, reduce, and reuse organic solvents in peptide downstream processing: the benefits of dimethyl carbonate over acetonitrile

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC01158B, Paper
Open Access Open Access
Chiara De Luca, Chiara Nosengo, Matteo Spedicato, Laura Magagnato, Giacomo Fogli, Marco Carraro, Walter Cabri, Marco Macis, Alberto Cavazzini, Simona Felletti, Antonio Ricci, Martina Catani
Replacement of acetonitrile with greener alternatives in reversed phase liquid chromatogrpahy for the purification of therapeutic peptides in industrial downstream processing.
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