Precipitation-first synthesis and deep profiling of a 1200-member acrylamide library for covalent drug discovery

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC04440E, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Pravin Patil, Emis Ingenito, Riccardo Fusco, Imma Capriello, Zhirui Guan, Anuja Bhalkikar, John Gibbons, Tomas Korba, Stanislav Bashkyrtsev, Oleh Tkachenko, Alexander Dömling
We developed an efficient Ugi-based route to 1200 acrylamides, delivering millimolar quantities of pure precipitated products. Library quality was verified by 1H NMR, UPLC-UV-MS, and AEMS, yielding a sustainable drug-discovery-ready set.
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