Late-stage C–H amidation of pharmaceuticals enabled by earth-abundant Co(III)-catalysis

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC06524K, Communication
Daniele Antermite, Elisa Y. Lai, João C. A. Oliveira, Stig D. Friis, Johan R. Johansson, Lutz Ackermann, Magnus J. Johansson
Cobalt-catalysis enables single-step late-stage C–H amidation of pharmaceuticals under mild, chemoselective conditions in a green solvent with broad functional group tolerance, reducing step counts and predicted PMI versus traditional strategies.
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