Overcoming protic-solvent limitations in dithiane chemistry: photocatalyzed Giese addition and one-pot ketone synthesis

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC01635A, Paper
Shafrizal Rasyid Atriardi, Hanifah Mardhiyah, Su Hyeon Kim, Sang Kook Woo
Dithiane umpolung provides valuable acyl anion synthons but suffers from protic solvent incompatibility. Commercially available TMS-dithiane as a radical precursor enables sustainable umpolung chemistry compatible with aqueous and alcoholic media.
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