Concise chemical synthesis of O-linked glycans

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC01945E, Paper
Yaohao Li, Wenqiang Liu, Chunyu Jin, Huanjie Zhu, Zerun Song, Jiongkun Peng, Chong Guo, Zhongping Tan
A concise divergent strategy affords 10 core-1 type O-linked glycoamino acid building blocks. Their availability enables homogeneous GHRH glycoform preparation and reveals that Thr7 O-glycosylation improves proteolytic stability against DPP-IV.
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