A general module assembly strategy for the generation of chondroitin sulfate polymers

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC03905C, Paper
Pengfei Li, Mengyuan Wang, Lin Yang, Yi Li, Jingyao Qu, Peixue Ling, Shuang Li, Junqiang Fang
A module assembly strategy was developed using expressed sulfotransferases and PAPS generation to efficiently synthesize CS-A, CS-E, and CS-C with defined sulfation patterns and high conversion rates, facilitating study of sulfation modifications.
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