Breaking through acetone inhibition: integrated protein engineering and bioreactor design for sustainable chiral aryl alcohol synthesis

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC02816G, Paper
Feng Qian, Yaowu Wang, Zhe Wang, Hanyu Liu, Ying Zhang, Haimin Zhang, Pu Wang
An efficient and eco-friendly strategy combining an engineered carbonyl reductase with an in situ acetone removal bioreactor (EIARB) tackled acetone inhibition during the bioreduction of aryl ketone in a neat isopropanol reaction system.
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