Comment on “L-Proline-promoted three-component reaction of anilines, aldehydes and barbituric acids/malononitrile: regioselective synthesis of 5-arylpyrimido[4,5-b]quinoline-diones and 2-amino-4-arylquinoline-3-carbonitriles in water” by A. Khalafi-Nezhad, S. Sarikhani, E. Shaikhi Shahidzadeh and F. Panahi, Green Chem., 2012, 14, 2876

Green Chem., 2025, Advance Article
DOI: 10.1039/D4GC02524E, Comment

Ting Chen, Syrine Mahdadi, Stéphanie Desbène-Finck
A one-pot synthesis of 5-phenyl-5,10-dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione from barbituric acid, benzaldehyde, and aniline gave high yields. Structural analysis confirmed a linear structure, unlike Khalafi-Nezhad’s report.
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