Continuous flow synthesis of cyclobutenes via lithium ynolates

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Green Chem., 2025, Advance Article
DOI: 10.1039/D4GC05102E, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Aki Kohyama, Motoki Namioka, Hiroshi Naka, Yosuke Ashikari, Aiichiro Nagaki, Hiroshi Takikawa, Yousuke Yamaoka, Kiyosei Takasu
Batch reactions that involve the generation of highly reactive species require a cryogenic temperature, complicated manipulations by chemists, and higher amounts of reagents, resulting in energy wastage and high costs.
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