De novo biosynthesis of 4,6-dihydroxycoumarin in Escherichia coli

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Green Chem., 2025, Advance Article
DOI: 10.1039/D4GC05694A, Paper
Open Access Open Access
Qi Gan, Tian Jiang, Chenyi Li, Xinyu Gong, Jianli Zhang, Bhaven K. Desai, Yajun Yan
By combining protein engineering and synthetic biology strategies, the novel de novo biosynthesis of 4,6-dihydroxycoumarin from glycerol was realized in Escherichia coli for the first time.
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