Dynamic conformation-aware protein language modeling enables structure-guided engineering of Candida antarctica lipase B

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC00310A, Paper
Yuqi Dong, Jidong Shen, Meng Zhang, Lianggang Huang, Xiaojian Zhang, Zhiqiang Liu, Yuguo Zheng
This study presents a dynamic conformation-aware protein language modeling (DC-PLM) strategy for engineering Candida antarctica lipase B (CALB), enabling enhanced long-chain ester hydrolysis and green valorization of industrial waste oils.
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