Functional-group compatible electrooxidation synthesis of the key antibiotic intermediate rifamycin O

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC04424C, Paper
Lihao Liu, Shaoming Zhu, Kai Li, Yuhang Wang, Suiqin Li, Jiahui He, Pan Hu, Chuang Qi, Ruixiang Liang, Xing Zhong, Jianguo Wang
A novel method of synthesizing the key antibiotic intermediate rifamycin O through the electrooxidation of rifamycin B (RB) was presented. Trace water addition enhanced the electrooxidation efficiency, achieving high yield and space–time yield.
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