Minute-level alkylation of heteroarenes via a photo-Fenton mechanism in continuous flow

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC05263G, Paper
Xiaobin Ge, Lijun Yuan, Qiqi Sun, Ting Lin, Weihao Chen, Ji Sun, Huangchao Yu, Jian Jin, Feng Liu, Hui He, Guoqiang Xu, Fabrice Gallou, Ning Ye, Yiming Mo, Xiaodong Shen
A photo-Fenton flow protocol that converts inexpensive H2O2 into ˙OH radical using a ferrocenyl diphenylphosphine oxide photocatalyst was developed for downstream hydrogen atom abstraction, enabling the minute-level alkylation of heterocycles.
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