Multi-substrate conversion synchronous cofactor-regeneration for efficient natural product biosynthesis

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC01315E, Communication
Chaofeng Li, Yeyun Wu, Fei Gu, Jiawei Wang, Yicheng Xu, Chao Liao, Liangxu Liu, Zhi Lin, Jun Ni
The MSCR strategy couples oxidation and reduction reactions for bidirectional cofactor recycling without sacrificial agents, achieving 94.68% conversion of rhododendrol (RD) and 4-hydroxybenzylideneacetone (4-HBA) to raspberry ketone.
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