Researchers at North Carolina State University (NC State), supported by BioMADE, have created a new framework to solve a major challenge in biotech manufacturing. The project, titled “Fluorescence and Raman Spectroscopy for Scaled-Down in Situ Product Monitoring,” aims to make scaling up bioprocesses easier and more reliable.
The team used small microbioreactors combined with advanced statistical modeling to predict fermentation results. These results include biomass production and product yield at pilot scale. The research was carried out at NC State’s Biomanufacturing Training and Education Center (BTEC).
BTEC has strong ties to biotech investments in North Carolina. BTEC also plays a vital role in workforce development and education for the region’s manufacturing ecosystem.
This project addresses a key issue in bioindustrial processes. Traditionally, scaling from lab to industrial production has been difficult. Unpredictable performance during scale-up forced companies to rely on costly trial-and-error methods. This approach wastes time and resources, delaying product development.
The new framework offers a promising solution by providing more accurate predictions during early stages. It could reduce costs and accelerate the transition from research to commercial production. The research highlights broader benefits, including sustainability, economic growth, national security, and supply chain resilience.
Overall, this innovative work helps make biomanufacturing more efficient and sustainable. It holds potential to transform how biotech companies scale their processes, saving resources and supporting advanced manufacturing in North Carolina and beyond.
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- Source: https://worldbiomarketinsights.com/ncstate-develops-framework-to-improve-biomanufacturing-scale-up/
