Radical reductive formylation of N-heteroarenes with formic acid under catalyst- and solvent-free conditions

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC01788B, Paper
Shaofeng Pang, Qi Wei, Junxi Liang, Liqun Jiang, Xinyun Guan, Bolin Xia, Rong Shang, Yanbin Wang, Yujing Zhang
A catalyst- and solvent-free system for reductive formylation of N-heteroarenes with formic acid was developed via a radical-mediated hydrogen transfer strategy to obtain N-formyl-heterocycles.
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