Structure–function mapping of host defense peptide mimics reveals strategies for antibacterial activity and eradication of mature bacterial biofilms

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC05877E, Paper
Open Access Open Access
Xueyang Yin, Yufang Bi, Xiehe Wang, Jing Ren, Jinrong Yao, Xin Chen, Shengjie Ling, Zhengzhong Shao
Greener epoxide-α-amino acid N-carboxyanhydride (NCA) synthesis yields biodegradable host defense peptide (HDP) mimics that clear biofilms with reduced material and energy use.
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