Synergistic Au–Pd catalysis of Sonogashira couplings of terminal alkynes with aryl iodides in water

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC00513F, Communication
Yilin Zhao, Zhangrong Lou, Zhenhua Fan, Masahiko Yamaguchi, Sheng Zhang, Ming Bao
The first synergistic Pd/Au catalysis of Sonogashira couplings in water is described. Using 0.01 mol% Pd and 2 mol% Au cocatalysts, various terminal alkynes react with aryl iodides, furnishing aryl alkynes in up to 99% yield within 30 minutes.
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