Visible-light-mediated late-stage N-functionalization of unprotected peptides: introducing the aza-Zimmerman–O’Connell–Griffin reaction

Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC02108A, Communication

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Sara Bacaicoa, Mario Martos, Wilma Yhlen Graf, August Runemark, Ganesh H. Shinde, Ganesh S. Ghotekar, Henrik Sundén
A sustainable, reagent-free method for amide synthesis and peptide functionalization via photoinduced ZOG rearrangement. High-yielding, purification without chromatography, and driven solely by light—ideal for greener peptide modification.
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