7-Step flow synthesis of the anti-HBV nucleoside drug entecavir

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC02310J, Communication
Zhenzhen Wang, Yaling Li, Guo-Tai Zhang, Xianjing Zheng, Zhaowei Jiang, Pei Tang, Fen-Er Chen
A sustainable continuous-flow synthesis of the anti-HBV drug entecavir in 7 steps from commercially available (+)-Corey lactone diol was developed, featuring a key photocatalytic dehydrogenative decarboxyolefination reaction.
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