Synthetic autotrophic yeast enables high itaconic acid production from CO2 via integrated pathway and process design

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC03149D, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Özge Ata, Lisa Lutz, Michael Baumschabl, Diethard Mattanovich
We show that combining pathway and process engineering enables synthetic autotrophic K. phaffii to produce ∼12 g L−1 itaconic acid from CO2, highlighting the role of interplay between native and heterologous metabolic pathways and process design.
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