Resonant acoustic mixing for green guanylation: thiourea trioxide as a solid cyanamide surrogate toward guanidine carbonate salts

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC06606A, Paper
Dipak J. Fartade, Andrea Porcheddu, Francesco Basoccu
Herein, resonance acoustic mixing is demonstrated as an efficient method for solvent-reduced guanidine synthesis from amines using thiourea trioxide, affording in high yields while avoiding toxic solvents, picrates, and chromatography.
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