Solvent recycling in solid-phase peptide synthesis (SPPS): combination of a swellable macroporous polystyrene (SMPS) resin and green binary solvents

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC01716A, Paper
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mani Kaushal, Sikabwe Noki, Yuxing Yang, Chaoyang Wang, Cheng Zhang, Alesandra Basso, Simona Serban, Dan Wu, Yanjun Li, Xiaokang Kou, Ashish Kumar, Anamika Sharma, Beatriz G. de la Torre, Fernando Albericio
Solid-phase peptide synthesis (SPPS) relies heavily on hazardous solvents, such as N,N′-dimethylformamide (DMF), whose substitution by green solvents is proving more challenging than expected.
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