Cl radical-mediated electrochemical site-selective functionalization of cysteine residues in NaCl aqueous media

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Green Chem., 2026, Advance Article
DOI: 10.1039/D6GC00888G, Paper
Shuyan Han, Siyu Li, Yixuan Gao, Yuan Liu, Shuo Zhang, Yanyan He, Hongfang Li, Teck-Peng Loh
A chlorine radical-mediated electrochemical strategy, enabling scalable cysteine functionalization, exhibits good functional group tolerance and enables successful protein modification.
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