Precision-engineered STING agonist nanoparticles enable coordinated mucosal-systemic immunity for durable pan-β-coronavirus protection

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Nature Nanotechnology, Published online: 17 June 2026; doi:10.1038/s41565-026-02188-z

A nanoparticle adjuvant that safely targets the STING pathway via intranasal administration generates potent mucosal and systemic immunity against diverse coronaviruses in preclinical models and converts existing intramuscular flu vaccines into effective nasal sprays.

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