A bio-inspired environmentally friendly and cost-effective chemo-enzymatic synthesis of (−)-ambrox from trans-nerolidol

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC05456G, Paper
Jianlin Liu, Yi Zhang, Shaoping Zhang, Changle Zhao, Ganlu Zhang, Shengbin Zhou, Xiaoguang Yan, Weiguo Li, Qinggele Caiyin, Jianjun Qiao
An efficient chemo-enzymatic synthetic route of (−)-ambrox is established, leveraging the inexpensive starting material trans-nerolidol provided by de novo biosynthesis in Saccharomyces cerevisiae at a titre of 26.4 g L−1.
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