Electrochemical α-hydroxylation of aryl ketones with methanol as the oxygen source

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC00758E, Communication
Zhaoliang Yang, Jianwei Huang, Yahao Wang, Haiyan Du, Yuan Zhou, Mingming Yu
We developed an electrochemical method for direct α-C(sp3)–H hydroxylation of aryl ketones using methanol as an oxygen donor and Br as redox mediators. Notably, the use of CD3OD enables direct synthesis of α-deuterated hydroxyketones.
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