Electrochemical regioselective synthesis of sulfonyl 2,5-dihydrofuran-fused spiropyrimidines via multi-component radical cascade reactions

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Green Chem., 2025, Advance Article
DOI: 10.1039/D4GC05637J, Paper
Qi-Liang Yang, Rong-Yi Xu, Cheng-Yang Ni, Xin Liu, Zu-Lin Qiao, Qi-Ying Zhang, Dong-Chao Wang, Hai-Ming Guo
In this work, we developed an efficient, eco-friendly electrochemical three-component one-pot method for the regioselective preparation of polysubstituted 2,5-dihydrofuran-fused spiropyrimidines with valuable –SO2R and –OR functional groups.
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