Heterogeneous Fe single-atom catalysis for C2–H amidation of pyridine/quinoline N-oxides: streamlined synthesis of pharmaceutical scaffolds

Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC03797B, Paper

Jinhua Ou, Song Yu, Duoduo Liu, Han Jiang, Can Lyu, Keyi Chen, Jie Li, Zhuobin Yu, Kaijian Liu, Jinxuan Liu
This first heterogeneous catalytic system enables base/additive-free C2–H amidation of N-oxides with 100% atom economy for pharmaceutical synthesis.
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