Intramolecular nitrogen insertion of oxime ester to access aminated N-heterocycles

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC02482J, Communication
Han Wang, Jing Feng, Dan-Ni Liu, Mingming Yu, Ze-Feng Xu, Chuan-Ying Li
A strategy for intramolecular nitrogen insertion of ketoxime esters to access aminated N-heterocycles is developed. It shows broad functional group tolerance, enables quetiapine fumarate synthesis, highlighting practical utility.
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