Protein dynamics-assisted engineering of a selective debenzylase for replacing Pd/C-catalyzed debenzylation in statin precursor synthesis

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Green Chem., 2026, Advance Article
DOI: 10.1039/D5GC05033B, Paper
Jianfeng Lin, Xuri Wu, Yijun Chen
This work presents the first enzymatic debenzylation as a green alternative to Pd/C-catalyzed hydrogenation. Using CoDyPAM approach, dynamic conformational analyses identify challenging distal hotspots for enzyme engineering.
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