Resonant acoustic mixing enables solvent-less amide coupling in solid-phase peptide synthesis

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Green Chem., 2025, Advance Article
DOI: 10.1039/D5GC04067A, Paper
Open Access Open Access
Alice Nanni, Panayiotis Bilalis, Magnus Rueping
Resonant acoustic mixing (RAM) as a mechanochemical alternative to traditional SPPS processes enables efficient and scalable peptide coupling without added solvent, supporting sustainable synthesis of bioactive peptides.
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